Emx1^{tm1.1(flpo)Jmac}
Targeted Allele Detail

Summary

• Symbol: Emx1^{tm1.1(flpo)Jmac}
• Name: empty spiracles homeobox 1; targeted mutation 1.1, Jeffrey D Macklis
• MGI ID: MGI:7444792
• Synonyms: Emx1-IRES-FlpO
• Gene: Emx1 Location: Chr6:85164913-85181445 bp, + strand Genetic Position: Chr6, 37.21 cM
• Alliance: Emx1^{tm1.1(flpo)Jmac} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Emx1^{tm1.1(flpo)Jmac} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Emx1 (MGI:95387)

• Mutation details: By standard gene targeting procedures, an IRES-FlpO cassette was introduced into the 3' untranslated region of the Emx1 gene followed by a loxP-flanked neomycin resistance (neo) cassette. Flp-mediated recombination removed the neo cassette. (J:328745)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Emx1 (mouse) Summary of all recombinase alleles driven by Emx1. Alliance mouse Emx1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Emx1 Mutation: 34 strains or lines available

References

• Original: J:328745 Sahni V, et al., Corticospinal neuron subpopulation-specific developmental genes prospectively indicate mature segmentally specific axon projection targeting. Cell Rep. 2021 Oct 19;37(3):109843
• All: 3 reference(s)