Srebf1^em1Hshim
Endonuclease-mediated Allele Detail

Summary

• Symbol: Srebf1^em1Hshim
• Name: sterol regulatory element binding transcription factor 1; endonuclease-mediated mutation 1, Hitoshi Shimano
• MGI ID: MGI:7444486
• Synonyms: SREBP-1a flox
• Gene: Srebf1 Location: Chr11:60089915-60113407 bp, - strand Genetic Position: Chr11, 37.81 cM
• Alliance: Srebf1^em1Hshim page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: CRISPR-targeting floxed exon 1a. This conditional allele prevents expression of the a isoform when combined with a cre recombinase. (J:333931)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srebf1 Mutation: 59 strains or lines available

References

• Original: J:333931 Araki M, et al., Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol. 2022 Dec 1;323(6):G627-G639
• All: 2 reference(s)