Lgi2^tm1.1Mejr
Targeted Allele Detail

Summary

• Symbol: Lgi2^tm1.1Mejr
• Name: leucine-rich repeat LGI family, member 2; targeted mutation 1.1, Dies Meijer
• MGI ID: MGI:7444273
• Synonyms: Lgi2^LoxP
• Gene: Lgi2 Location: Chr5:52690859-52723689 bp, - strand Genetic Position: Chr5, 28.25 cM
• Alliance: Lgi2^tm1.1Mejr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:333962
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 1 and an FRT-flanked neomycin resistance cassette with a 3' loxP site downstream of exon 1. Flp-mediated recombination removed the selection cassette and left exon 1 floxed. (J:333962)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgi2 Mutation: 26 strains or lines available

References

• Original: J:333962 Kozar-Gillan N, et al., LGI3/2-ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period. J Cell Biol. 2023 Apr 3;222(4)
• All: 1 reference(s)