Mlx^tm1.1Rne
Targeted Allele Detail

Summary

• Symbol: Mlx^tm1.1Rne
• Name: MAX-like protein X; targeted mutation 1.1, Robert N Eisenman
• MGI ID: MGI:7444087
• Synonyms: Mlx floxed
• Gene: Mlx Location: Chr11:100978103-100983033 bp, + strand Genetic Position: Chr11, 64.18 cM, cytoband D
• Alliance: Mlx^tm1.1Rne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324060
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a loxP site and FRT flanked neomycin cassette were inserted downstream of exon 6 via homologous recombination. FLP-mediated recombination removed the neomycin selection cassette, leaving loxP sites flanking exons 3-6. (J:324060)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mlx Mutation: 18 strains or lines available

References

• Original: J:324060 Carroll PA, et al., The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis. PLoS Biol. 2021 Oct;19(10):e3001085
• All: 3 reference(s)