Gt(ROSA)26Sor^{em1(CAG-Psme3)Lixt}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-Psme3)Lixt}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Xiaotao Li
• MGI ID: MGI:7444047
• Synonyms: REGgamma KI
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-Psme3)Lixt} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{em1(CAG-Psme3)Lixt} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Psme3 (MGI:1096366)

• Mutation details: CRISPR/Cas9 technology inserted a CAG promoter, loxP-flanked STOP cassette, mouse Psme3 coding sequence with a 1x FLAG tag and polyA into the locus between exons 1 and 2.. The mouse Psme3 is expressed only after recombinase-mediated removal of the STOP cassette. (J:333880)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1205 strains or lines available

References

• Original: J:333880 Tu J, et al., Aging-associated REGgamma proteasome decline predisposes to tauopathy. J Biol Chem. 2022 Nov;298(11):102571
• All: 1 reference(s)