About   Help   FAQ
Targeted Allele Detail
Symbol: Qpcttm1.1Gne
Name: glutaminyl-peptide cyclotransferase (glutaminyl cyclase); targeted mutation 1.1, Genentech
MGI ID: MGI:7442902
Gene: Qpct  Location: Chr17:79359335-79397807 bp, + strand  Genetic Position: Chr17, 49.83 cM, cytoband E3
Alliance: Qpcttm1.1Gne page
Germline Transmission:  Earliest citation of germline transmission: J:324112
Parent Cell Line:  C2 (Nagy) (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe targeted mutation deleted exon 1 and 20bp of intron 1. Flp-mediated recombination removed the FRT-flanked selection cassette. (J:324112)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Qpct Mutation:  8 strains or lines available
Original:  J:324112 Barreira da Silva R, et al., Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity. Nat Immunol. 2022 Apr;23(4):568-580
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.24
The Jackson Laboratory