Gzmb^tm1.1Xcao
Targeted Allele Detail

Summary

• Symbol: Gzmb^tm1.1Xcao
• Name: granzyme B; targeted mutation 1.1, Xuefang Cao
• MGI ID: MGI:7442681
• Synonyms: GzmB^fl
• Gene: Gzmb Location: Chr14:56496295-56499717 bp, - strand Genetic Position: Chr14, 28.19 cM, cytoband D3
• Alliance: Gzmb^tm1.1Xcao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:333854
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site is inserted at the first AvrII site, whicht is approximately 20bp upstream of the ATG start codon in exon 1. A self-excising neomycin cassette and loxP site were placed in intron 1 (J:333854)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gzmb Mutation: 35 strains or lines available

References

• Original: J:333854 Tibbs E, et al., Murine myeloid derived suppressor cells possess a range of suppressive mechanisms-Granzyme B is not among them. Cancer Immunol Immunother. 2022 Sep;71(9):2255-2266
• All: 1 reference(s)