Foxo1^em1Fcw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Foxo1^em1Fcw
• Name: forkhead box O1; endonuclease-mediated mutation 1, Fengchao Wang
• MGI ID: MGI:7442524
• Synonyms: Foxo1^mut
• Gene: Foxo1 Location: Chr3:52175758-52257530 bp, + strand Genetic Position: Chr3, 23.19 cM
• Alliance: Foxo1^em1Fcw page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• CRISPR-targeting disrupted the demethylation motif (ttGGACT to ctCGATT). (J:273800)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxo1 Mutation: 34 strains or lines available

References

• Original: J:273800 Peng S, et al., Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci Transl Med. 2019 Apr 17;11(488)
• All: 1 reference(s)