Tcfl5^em#Wux
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tcfl5^em#Wux
• Name: transcription factor-like 5 (basic helix-loop-helix); endonuclease-mediated mutation, Xin Wu
• MGI ID: MGI:7442315
• Gene: Tcfl5 Location: Chr2:180263749-180284501 bp, - strand Genetic Position: Chr2, 103.16 cM
• Alliance: Tcfl5^em#Wux page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-cas9 mediated recombination using guide RNAs targeting exons 1-4 was used to create 4 lines with either deletions or insertions and deletions. Data for all 4 lines were pooled. (J:324154)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcfl5 Mutation: 12 strains or lines available

References

• Original: J:324154 Xu W, et al., Transcription factor-like 5 is a potential DNA- and RNA-binding protein essential for maintaining male fertility in mice. J Cell Sci. 2022 Feb 1;135(3):jcs259036
• All: 1 reference(s)