Becn2^em1Hec
Endonuclease-mediated Allele Detail

Summary

• Symbol: Becn2^em1Hec
• Name: beclin 2; endonuclease-mediated mutation 1, Congcong He
• MGI ID: MGI:7442265
• Synonyms: Becn2^S97L
• Gene: Becn2 Location: Chr1:175747895-175749791 bp, + strand Genetic Position: Chr1, Syntenic
• Alliance: Becn2^em1Hec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314992
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-cas9 mediated recombination created a TCT to TTG mutation, resulting in an S to L substitution at amino acid 97, and inserted a floxed neo cassette upstream of exon 1. (J:314992)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Becn2 Mutation: 4 strains or lines available

Notes

Lentiviral gene trap injected into zygotes.

References

• Original: J:314992 Kim YJ, et al., An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system. Sci Adv. 2021 Feb;7(8)
• All: 1 reference(s)