Cyp8b1^em1Lky
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cyp8b1^em1Lky
• Name: cytochrome P450, family 8, subfamily b, polypeptide 1; endonuclease-mediated mutation 1, Richard M Locksley
• MGI ID: MGI:7442199
• Synonyms: Cyp8b1^-
• Gene: Cyp8b1 Location: Chr9:121743422-121745371 bp, - strand Genetic Position: Chr9, 72.73 cM, cytoband F4
• Alliance: Cyp8b1^em1Lky page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting introduced a 1.2-kb deletion in the coding region. (J:333765)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp8b1 Mutation: 33 strains or lines available

References

• Original: J:333765 O'Leary CE, et al., Bile acid-sensitive tuft cells regulate biliary neutrophil influx. Sci Immunol. 2022 Mar 4;7(69):eabj1080
• All: 1 reference(s)