Klhl3^em1Jkmi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Klhl3^em1Jkmi
• Name: kelch-like 3; endonuclease-mediated mutation 1, Jeong-Ki Min
• MGI ID: MGI:7439100
• Gene: Klhl3 Location: Chr13:58148042-58261406 bp, - strand Genetic Position: Chr13, 30.92 cM
• Alliance: Klhl3^em1Jkmi page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology generated a 2 bp insertion resulting in a frameshift mutation and a stop codon at residue 81. (J:333487)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klhl3 Mutation: 43 strains or lines available

References

• Original: J:333487 Jang JH, et al., KLHL3 deficiency in mice ameliorates obesity, insulin resistance, and nonalcoholic fatty liver disease by regulating energy expenditure. Exp Mol Med. 2022 Aug;54(8):1250-1261
• All: 1 reference(s)