Prdm1tm5.1(cre/ERT2)Rob
Targeted Allele Detail
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Symbol: |
Prdm1tm5.1(cre/ERT2)Rob |
Name: |
PR domain containing 1, with ZNF domain; targeted mutation 5.1, Elizabeth J Robertson |
MGI ID: |
MGI:7438442 |
Synonyms: |
Prdm1CreERT2, Prdm1CreERT2-LacZ |
Gene: |
Prdm1 Location: Chr10:44313173-44404497 bp, - strand Genetic Position: Chr10, 23.24 cM
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Alliance: |
Prdm1tm5.1(cre/ERT2)Rob page
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Germline Transmission: |
Earliest citation of germline transmission:
J:257197
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Inducible, Recombinase, Reporter) |
Mutation: |
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Insertion
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Prdm1tm5.1(cre/ERT2)Rob expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Prdm1 (MGI:99655) |
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Mutation details: The allele was generated by introducing a cassette containing a CreERT2 upstream of IRES-nlacZ followed by a FRT-flanked neo cassette (CreERT2-IRES-nLacZ-FRT-neo-FRT) into the ATG translational site in exon 3 of the Prdm1 gene via homologous recombination in embryonic stem (ES) cells. Correctly targeted ES cell clones were transiently transfected with a FLP expression construct to excise the neo cassette.
(J:257197)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Prdm1
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Prdm1 Mutation: |
64 strains or lines available
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Original: |
J:257197 Elias S, et al., Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life. Nat Commun. 2017 Nov 20;8(1):1714 |
All: |
1 reference(s) |
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