Kcnj1^tm1Twan
Targeted Allele Detail

Summary

• Symbol: Kcnj1^tm1Twan
• Name: potassium inwardly-rectifying channel, subfamily J, member 1; targeted mutation 1, Tong Wang
• MGI ID: MGI:7438379
• Synonyms: Romk1^flox
• Gene: Kcnj1 Location: Chr9:32283789-32310493 bp, + strand Genetic Position: Chr9, 17.69 cM
• Alliance: Kcnj1^tm1Twan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231022
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The exon encoding isoform 1 (Romk1) was flanked by loxP sites and a PGK neomycin resistance gene and third loxP site was inserted downstream of the floxed exon. (J:231022)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnj1 Mutation: 26 strains or lines available

References

• Original: J:231022 Dong K, et al., Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion. J Biol Chem. 2016 Mar 4;291(10):5259-69
• All: 1 reference(s)