Crhr1^{tm1.1(cre/GFP)Lsz}
Targeted Allele Detail

Summary

• Symbol: Crhr1^{tm1.1(cre/GFP)Lsz}
• Name: corticotropin releasing hormone receptor 1; targeted mutation 1.1, Larry S Zweifel
• MGI ID: MGI:7438225
• Synonyms: Crhr1^IRES-Cre
• Gene: Crhr1 Location: Chr11:104023681-104066349 bp, + strand Genetic Position: Chr11, 67.77 cM
• Alliance: Crhr1^{tm1.1(cre/GFP)Lsz} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253267
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• Crhr1^{tm1.1(cre/GFP)Lsz} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Crhr1 (MGI:88498)

• Mutation details: An IRES-CreGFP sequence and frt-flanked neomycin gene were inserted into the 3 UTR of the endogenous Crhr1 gene. The neomycin resistance cassette was removed by crossing F1 offspring to FlpEr mice. (J:253267)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Crhr1 (mouse) Summary of all recombinase alleles driven by Crhr1. Comparative matrix view of recombinase activities Alliance mouse Crhr1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crhr1 Mutation: 26 strains or lines available

References

• Original: J:253267 Sanford CA, et al., A Central Amygdala CRF Circuit Facilitates Learning about Weak Threats. Neuron. 2017 Jan 4;93(1):164-178
• All: 2 reference(s)