Sox7^tm2.1Inki
Targeted Allele Detail

Summary

• Symbol: Sox7^tm2.1Inki
• Name: SRY (sex determining region Y)-box 7; targeted mutation 2.1, Injune Kim
• MGI ID: MGI:7438004
• Synonyms: Sox7^fl
• Gene: Sox7 Location: Chr14:64181155-64188181 bp, + strand Genetic Position: Chr14, 33.34 cM, cytoband C3
• Alliance: Sox7^tm2.1Inki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251608
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette and loxP site were inserted upstream of the first exon and second loxP site was inserted downstream of exon 1. The neomycin selection cassette was removed via flp-mediated recombination leaving exon 1 floxed. (J:251608)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox7 Mutation: 21 strains or lines available

References

• Original: J:251608 Kim K, et al., SoxF Transcription Factors Are Positive Feedback Regulators of VEGF Signaling. Circ Res. 2016 Sep 16;119(7):839-52
• All: 2 reference(s)