Tiparp^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tiparp^em1Cya
• Name: TCDD-inducible poly(ADP-ribose) polymerase; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7437859
• Synonyms: Tiparp^H532A
• Gene: Tiparp Location: Chr3:65435868-65462939 bp, + strand Genetic Position: Chr3, 30.2 cM
• Alliance: Tiparp^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting introduced the mutation (CAT to GCC) responsible for the amino acid substitution of histidine with alanine at position 532 (H532A). (J:333389)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tiparp Mutation: 44 strains or lines available

References

• Original: J:333389 Hutin D, et al., 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (TiparpH532A) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality. Toxicol Sci. 2021;183(1):154-169
• All: 2 reference(s)