Dlg4^tm1.1Mzlin
Targeted Allele Detail

Summary

• Symbol: Dlg4^tm1.1Mzlin
• Name: discs large MAGUK scaffold protein 4; targeted mutation 1.1, Michael Lin
• MGI ID: MGI:7437481
• Synonyms: PSD95-lox-Stop-lox-TimeSTAMP2
• Gene: Dlg4 Location: Chr11:69908029-69938107 bp, + strand Genetic Position: Chr11, 42.96 cM, cytoband B4
• Alliance: Dlg4^tm1.1Mzlin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to replace the endogenous STOP codon of the gene with a loxP-flanked STOP codon (TAGTGA), a TimeSTAMP cassette with a STOP codon, and an FRT-flanked neomycin (neo) cassette. The TimeSTAMP (Time-Specific Tagging for the Age Measurement of Proteins) cassette contains, from 5'; to 3', N-terminal Venus fragment, a cis-cleaving hepatitis C virus (HCV) NS3 protease, C-terminal Venus fragment, and two hemagglutinin (2xHA) tags. Flp-mediated recombination removed the neo cassette. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlg4 Mutation: 52 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)