Cgas^em1Minh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cgas^em1Minh
• Name: cyclic GMP-AMP synthase; endonuclease-mediated mutation 1, Minhong Yan
• MGI ID: MGI:7435745
• Synonyms: cGAS^-
• Gene: Cgas Location: Chr9:78337808-78350519 bp, - strand Genetic Position: Chr9, 43.65 cM
• Alliance: Cgas^em1Minh page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using sgRNAs 5- GTATACTGTTCCAACACAGG-3 and 5-TGACCGCACGACTTACCCTG-3 deleted exon 2. (J:288823)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cgas Mutation: 26 strains or lines available

References

• Original: J:288823 Zhou Y, et al., Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP. Immunity. 2020 Feb 18;52(2):357-373.e9
• All: 1 reference(s)