Pum1^tm1.2Eyx
Targeted Allele Detail

Summary

• Symbol: Pum1^tm1.2Eyx
• Name: pumilio RNA-binding family member 1; targeted mutation 1.2, Eugene Yujun Xu
• MGI ID: MGI:7435018
• Gene: Pum1 Location: Chr4:130390632-130508875 bp, + strand Genetic Position: Chr4, 63.43 cM
• Alliance: Pum1^tm1.2Eyx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283575
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 9 and 10 were flanked by loxP elements and a Neomycin selection cassette flanked with FRT sequences. FLP-mediated recombination resulted in the removal of the promoter-driven neomycin selection cassette and Cre-mediated recombination in the germline resulted in the removal of exons 9 and 10. (J:283575)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pum1 Mutation: 168 strains or lines available

References

• Original: J:283575 Lin K, et al., Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b. Cell Rep. 2019 Feb 26;26(9):2434-2450.e6
• All: 1 reference(s)