Scn5a^{tm5(SCN5A*)Rdn}
Targeted Allele Detail

Summary

• Symbol: Scn5a^{tm5(SCN5A*)Rdn}
• Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 5, Dan M Roden
• MGI ID: MGI:7434557
• Synonyms: Scn5a^R222Q
• Gene: Scn5a Location: Chr9:119312474-119408082 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Scn5a^{tm5(SCN5A*)Rdn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:333144
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The targeting construct replaced exon 2 with the corresponding human sequence with the mutation responsible for the amino acid substitution of arginine with glutamine at position 222 (R222Q). (J:333144)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scn5a Mutation: 103 strains or lines available

References

• Original: J:333144 Daniel LL, et al., SCN5A variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells. Heart Rhythm. 2019;16(11):1676-1685
• All: 1 reference(s)