Nfe2l2^tm1.1Vu
Targeted Allele Detail

Summary

• Symbol: Nfe2l2^tm1.1Vu
• Name: nuclear factor, erythroid derived 2, like 2; targeted mutation 1.1, Vanderbilt University
• MGI ID: MGI:7434556
• Synonyms: Nfe2l2^flox
• Gene: Nfe2l2 Location: Chr2:75505857-75534985 bp, - strand Genetic Position: Chr2, 44.75 cM
• Alliance: Nfe2l2^tm1.1Vu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:333141
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exons 4 and 5. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:333141)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfe2l2 Mutation: 90 strains or lines available

References

• Original: J:333141 Traver G, et al., Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung. Free Radic Biol Med. 2017 Nov;112:578-586
• All: 1 reference(s)