Tg(CASP4)1Bux
Transgene Detail

Summary

• Symbol: Tg(CASP4)1Bux
• Name: transgene insertion 1, Joseph Buxbaum
• MGI ID: MGI:7433250
• Transgene: Tg(CASP4)1Bux Location: unknown
• Alliance: Tg(CASP4)1Bux page

Transgene origin

• Strain of Origin: C57BL/6 x C3

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CASP4)1Bux expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CASP4 (837)

  Casp4

  (MGI:107700)

• Mutation details: The human CASP4 transgenic construct contains the entire human CASP4 gene and 6.8 kb of upstream sequences including the promoter region (bacterial artificial chromosome clone, RP11 693N9). The BAC clone also includes the long isoform of CASP12 (carrying a single nucleotide variant found in a small proportion of humans with African ancestry). The long isoform is catalytically inactive but acts to suppress LPS-induced cytokine secretion and NFKB activation. (J:256722)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:256722 Kajiwara Y, et al., A critical role for human caspase-4 in endotoxin sensitivity. J Immunol. 2014 Jul 1;193(1):335-43
• All: 1 reference(s)