Parp9^tm1.1Vshr
Targeted Allele Detail

Summary

• Symbol: Parp9^tm1.1Vshr
• Name: poly (ADP-ribose) polymerase family, member 9; targeted mutation 1.1, Valerie Schreiber
• MGI ID: MGI:7432953
• Gene: Parp9 Location: Chr16:35759360-35792975 bp, + strand Genetic Position: Chr16, 25.43 cM
• Alliance: Parp9^tm1.1Vshr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246409
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced exon 4 with an FRT site, loxP site, neomycin resistance cassette, FRT site, and floxed exon 4. Cre-mediated recombination removed exon 4 preventing expression of both the short and long isoforms. (J:246409)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Parp9 Mutation: 94 strains or lines available

References

• Original: J:246409 Robert I, et al., Robust immunoglobulin class switch recombination and end joining in Parp9-deficient mice. Eur J Immunol. 2017 Apr;47(4):665-676
• All: 1 reference(s)