Aanat^em2Liug
Endonuclease-mediated Allele Detail

Summary

• Symbol: Aanat^em2Liug
• Name: arylalkylamine N-acetyltransferase; endonuclease-mediated mutation 2, Guoshi Liu
• MGI ID: MGI:7432945
• Gene: Aanat Location: Chr11:116482547-116489022 bp, + strand Genetic Position: Chr11, 81.43 cM, cytoband E2
• Alliance: Aanat^em2Liug page

Mutation origin

• Strain of Origin: ICR

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-cas9 mediated recombination with guide RNAs targeting exon 3 created a 5 bp deletion and 1 bp insertion in the coding region. (J:317179)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aanat Mutation: 22 strains or lines available

References

• Original: J:317179 Yang M, et al., Melatonin promotes male reproductive performance and increases testosterone synthesis in mammalian Leydig cells. Biol Reprod. 2021 Jun 4;104(6):1322-1336
• All: 1 reference(s)