Cxcl12^tm1Ipek
Targeted Allele Detail

Summary

• Symbol: Cxcl12^tm1Ipek
• Name: C-X-C motif chemokine ligand 12; targeted mutation 1, Philipp von Hundelshausen
• MGI ID: MGI:7432870
• Synonyms: Cxcl12^flox
• Gene: Cxcl12 Location: Chr6:117145496-117158328 bp, + strand Genetic Position: Chr6, 54.81 cM, cytoband F1
• Alliance: Cxcl12^tm1Ipek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270132
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector replaced exons 1-3 with exon 1, an FRT-flanked neomycin selection cassette, exon 2 flanked by loxP sites and exon 3, generating an exon 2 floxed allele. (J:270132)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcl12 Mutation: 24 strains or lines available

References

• Original: J:270132 von Hundelshausen P, et al., Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. Sci Transl Med. 2017 Apr 05;9(384)
• All: 3 reference(s)