Isr(HSA6;SYNGAP1-ZBTB9)1Bpro
Allele Detail

Summary

• Symbol: Isr(HSA6;SYNGAP1-ZBTB9)1Bpro
• Name: interspecies replacement, human Chr 6, Benjamin L Prosser 1
• MGI ID: MGI:7432724
• Synonyms: Is(SYNGAP1-ZBTB9)1Bpro, Syngap1^hu
• Gene: Isr(HSA6;SYNGAP1-ZBTB9)1Bpro Location: unknown Genetic Position: Chr17, Syntenic

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Other (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Isr(HSA6;SYNGAP1-ZBTB9)1Bpro involves 2 genes/genome features (Syngap1, Zbtb9) View all
• Isr(HSA6;SYNGAP1-ZBTB9)1Bpro expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SYNGAP1 (8831)

  Syngap1

  (MGI:3039785)

  human

  ZBTB9 (221504)

  Zbtb9

  (MGI:1918022)

• Mutation details: The targeting vector contains from 5' to 3' a loxP site, an FRT-flanked neomycin cassette, a human genomic DNA 37.5kb BAC encoding SYNGAP1 and the adjacent ZBTB9 (ENSMUST00000194598.6) genes, an F3-flanked hygromycin, followed by a second loxP site is used to replace the entire genomic region of the Syngap1 and up to the STOP codon of the Zbtb9 gene. The insertion results in a knock-out of the mouse Syngap1 and Zbtb9 genes. Flp-mediated recombination removed the neo and hygro cassettes. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Isr(HSA6;SYNGAP1-ZBTB9)1Bpro Mutation: 0 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)