Strap^em2Pkda
Endonuclease-mediated Allele Detail

Summary

• Symbol: Strap^em2Pkda
• Name: serine/threonine kinase receptor associated protein; endonuclease-mediated mutation 2, Pran K Datta
• MGI ID: MGI:7432303
• Synonyms: Strap^fl
• Gene: Strap Location: Chr6:137712080-137728928 bp, + strand Genetic Position: Chr6, 67.27 cM
• Alliance: Strap^em2Pkda page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Zinc finger nucleases (ZFNs) technology inserted loxP sites in intron 2 and intron 4, flanking exons 3-4. This is a representative line used for the study. (J:332942)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Strap Mutation: 20 strains or lines available

References

• Original: J:332942 Vu T, et al., Serine-threonine Kinase Receptor-Associated Protein is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis Through a Feed-Forward Mechanism. Gastroenterology. 2022 Jan;162(1):193-208
• All: 1 reference(s)