Scg3^tm1Xen
Targeted Allele Detail

Summary

• Symbol: Scg3^tm1Xen
• Name: secretogranin III; targeted mutation 1, Taconic Biosciences
• MGI ID: MGI:7431441
• Gene: Scg3 Location: Chr9:75550471-75591338 bp, - strand Genetic Position: Chr9, 42.32 cM
• Alliance: Scg3^tm1Xen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332958
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A selection cassette replaced exon 1 containing the ATG start codon. Western blot analysis confirmed the absence of protein. (J:332958)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scg3 Mutation: 35 strains or lines available

References

• Original: J:332958 Dai C, et al., Secretogranin III stringently regulates pathological but not physiological angiogenesis in oxygen-induced retinopathy. Cell Mol Life Sci. 2022 Jan 10;79(1):63
• All: 4 reference(s)