Zfp423^tm2Ggc
Targeted Allele Detail

Summary

• Symbol: Zfp423^tm2Ggc
• Name: zinc finger protein 423; targeted mutation 2, Giacomo Consalez
• MGI ID: MGI:7431405
• Synonyms: Zfp423 delta28-30
• Gene: Zfp423 Location: Chr8:88388438-88686223 bp, - strand Genetic Position: Chr8, 42.29 cM, cytoband C4
• Alliance: Zfp423^tm2Ggc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245759
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette of the sequence corresponding to the exons 6 and 7 of the Zf423 gene with the nucleotides 3861-4108 of the ORF deleted and an FRT flanked neomycin selection cassette replaced the endogenous exons 6 and 7. It causes a frameshift mutation that produces a stop codon 158 bp into exon 8. The resulting C-termally trancated protein lacks zinc fingers 28-30 and 91 C-terminal amino acids. (J:245759)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp423 Mutation: 276 strains or lines available

References

• Original: J:245759 Casoni F, et al., Zfp423/ZNF423 regulates cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors. Development. 2017 Oct 15;144(20):3686-3697
• All: 2 reference(s)