Hnf1aosc^tm1.1Jfer
Targeted Allele Detail

Summary

• Symbol: Hnf1aosc^tm1.1Jfer
• Name: HNF1 homeobox A, opposite strand transcript cluster; targeted mutation 1.1, Jorge Ferrer
• MGI ID: MGI:7431278
• Synonyms: Haster^stop
• Gene: Hnf1aosc Location: unknown Genetic Position: Chr5, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332319
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A STOP cassette (3x SV40 pol(A) signal sequence) and an FRT site flanked neomycin resistance gene cassette were inserted downstream of Hnf1aos1 and Hnf1aos2 promoter/1st exon (inside Hnf1a intron 1). The neo cassette was removed through subsequent flp-mediated recombination. The insertion prematurely terminates transcription of Hnf1aos1 and Hnf1aos2. (J:332319)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hnf1aosc Mutation: 0 strains or lines available

References

• Original: J:332319 Beucher A, et al., The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A. Nat Cell Biol. 2022 Oct;24(10):1528-1540
• All: 1 reference(s)