Htt^tm6Szi
Targeted Allele Detail

Summary

• Symbol: Htt^tm6Szi
• Name: huntingtin; targeted mutation 6, Scott Zeitlin
• MGI ID: MGI:7431215
• Synonyms: Htt^deltaN17
• Gene: Htt Location: Chr5:34919084-35069878 bp, + strand Genetic Position: Chr5, 17.92 cM
• Alliance: Htt^tm6Szi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325879
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The wild-type exon 1 sequence was replaced with a sequence containing a deletion of amino acids 2-17 and thus lacking the N17 domain. (J:325879)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htt Mutation: 178 strains or lines available

References

• Original: J:325879 Andre EA, et al., Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion. J Huntingtons Dis. 2017;6(1):47-62
• All: 1 reference(s)