Prkci^Tvrm323
Chemically induced Allele Detail

Summary

• Symbol: Prkci^Tvrm323
• Name: protein kinase C, iota; translational vision research model 323
• MGI ID: MGI:7431171
• Gene: Prkci Location: Chr3:31049893-31106889 bp, + strand Genetic Position: Chr3, 14.65 cM
• Alliance: Prkci^Tvrm323 page

Mutation origin

• Strain of Origin: B6.Cg-Crb1^rd8/Pjn

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: The ENU-induced a T to A point mutation at position 406 (c.406T>A) resulting in a tyrosine to asparagine substitution at codon 136 (p.Y136N). (J:326080)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkci Mutation: 68 strains or lines available

References

• Original: J:326080 Weatherly SM, et al., Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model. PLoS Genet. 2022 Jun;18(6):e1009798
• All: 1 reference(s)