Acsf3^tm1Cpv
Targeted Allele Detail

Summary

• Symbol: Acsf3^tm1Cpv
• Name: acyl-CoA synthetase family member 3; targeted mutation 1, Charles P Venditti
• MGI ID: MGI:7431134
• Gene: Acsf3 Location: Chr8:123502225-123544619 bp, + strand Genetic Position: Chr8, 71.97 cM
• Alliance: Acsf3^tm1Cpv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326799
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 and C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The first coding exon (exon 2) was replaced with a loxP-flanked neomycin resistance cassette. (J:326799)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acsf3 Mutation: 33 strains or lines available

References

• Original: J:326799 Head PE, et al., Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin. Sci Transl Med. 2022 May 25;14(646):eabn4772
• All: 1 reference(s)