Senp3^tm1.1Nju
Targeted Allele Detail

Summary

• Symbol: Senp3^tm1.1Nju
• Name: SUMO/sentrin specific peptidase 3; targeted mutation 1.1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:7430910
• Synonyms: SENP3^flox
• Gene: Senp3 Location: Chr11:69563941-69572910 bp, - strand Genetic Position: Chr11, 42.86 cM, cytoband B4
• Alliance: Senp3^tm1.1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262771
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked IRES-lacZ/neomycin resistance gene cassette and loxP site were inserted upstream of exon 8 and a second loxP site was inserted downstream of the 3 UTR. The lacZ/neomycin selection cassette was removed via flp-mediated recombination leaving exons 8-11 and the 3 UTR floxed. (J:262771)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Senp3 Mutation: 32 strains or lines available

References

• Original: J:262771 Lao Y, et al., DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages. J Biol Chem. 2018 Mar 16;293(11):3965-3980
• All: 11 reference(s)