Sosttm1.1Ozg
Targeted Allele Detail
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Symbol: |
Sosttm1.1Ozg |
Name: |
sclerostin; targeted mutation 1.1, Ozgene |
MGI ID: |
MGI:7430798 |
Synonyms: |
Sostflox |
Gene: |
Sost Location: Chr11:101853284-101857841 bp, - strand Genetic Position: Chr11, 65.48 cM, cytoband D
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Alliance: |
Sosttm1.1Ozg page
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Germline Transmission: |
Earliest citation of germline transmission:
J:332799
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: The loxP sites flank the exon 1 of the murine Sost (sclerostin) gene without disrupting splicing or regulatory sequences. The FLPe recombinase removed the neomycin selection cassette.
(J:332799)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sost Mutation: |
34 strains or lines available
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Original: |
J:332799 O'Donohue AK, et al., Targeted postnatal knockout of Sclerostin using a bone-targeted adeno-associated viral vector increases bone anabolism and decreases canalicular density. Bone. 2022 Nov 30;167:116636 |
All: |
1 reference(s) |
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