Tg(Igkv3-5*-MYC)DLoxP10Plbe
Transgene Detail

Summary

• Symbol: Tg(Igkv3-5*-MYC)DLoxP10Plbe
• Name: transgene insertion DLoxP10, P Leif Bergsagel
• MGI ID: MGI:7430791
• Synonyms: Vk*MYCDLoxP
• Transgene: Tg(Igkv3-5*-MYC)DLoxP10Plbe Location: unknown Genetic Position: Chr4, Syntenic
• Alliance: Tg(Igkv3-5*-MYC)DLoxP10Plbe page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igkv3-5*-MYC)DLoxP10Plbe expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Myc	(MGI:97250)

• Mutation details: The mouse promoter drives B cell-specific expression of the human MYC coding sequence (exons 2 and 3; Genbank vector OQ428542). A codon mutation generates a STOP codon at the third codon (TCG to TAG) and prevents expression of MYC. The codon substitution created a DGYW motif, a known preferential target sequence for somatic hypermutation, that can activate MYC translation following sporadic reversion. This vector lacks the loxP site found in Tg(Igkv3-5*-MYC)24Plbe. In line 10, the transgene inserted at chr4:120761207-120761748 with deletion of intervening region, and a translocation to chr7:31992321-31992780. (J:131912)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:131912 Chesi M, et al., AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies. Cancer Cell. 2008 Feb;13(2):167-80
• All: 1 reference(s)