Sharpin^tm1.1Kiwa
Targeted Allele Detail

Summary

• Symbol: Sharpin^tm1.1Kiwa
• Name: SHANK-associated RH domain interacting protein; targeted mutation 1.1, Kazuhiro Iwai
• MGI ID: MGI:7429192
• Synonyms: Sharpin^fl
• Gene: Sharpin Location: Chr15:76231240-76235310 bp, - strand Genetic Position: Chr15, 35.75 cM
• Alliance: Sharpin^tm1.1Kiwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279330
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exons 3 through 9. Flp-mediated recombination removed the selection cassette. (J:279330)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sharpin Mutation: 27 strains or lines available

References

• Original: J:279330 Sasaki K, et al., Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death. Nat Commun. 2019 Aug 28;10(1):3878
• All: 1 reference(s)