Tnks2^tm1Yjc
Targeted Allele Detail

Summary

• Symbol: Tnks2^tm1Yjc
• Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; targeted mutation 1, Y Jeffrey Chiang
• MGI ID: MGI:7429093
• Synonyms: TANK2^flox
• Gene: Tnks2 Location: Chr19:36811632-36870877 bp, + strand Genetic Position: Chr19, 31.96 cM
• Alliance: Tnks2^tm1Yjc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106918
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP sequence flanked neo gene, employed as a positive selectable marker, was inserted upstream of exon 1, and a third loxP sequence was inserted downstream of exon 1. (J:106918)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnks2 Mutation: 48 strains or lines available

References

• Original: J:106918 Chiang YJ, et al., Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice. Mol Cell Biol. 2006 Mar;26(6):2037-43
• All: 4 reference(s)