Klhl24^em1Xtan
Endonuclease-mediated Allele Detail

Summary

• Symbol: Klhl24^em1Xtan
• Name: kelch-like 24; endonuclease-mediated mutation 1, Xu Tan
• MGI ID: MGI:7428974
• Synonyms: Klhl24^-
• Gene: Klhl24 Location: Chr16:19916292-19947971 bp, + strand Genetic Position: Chr16, 12.36 cM, cytoband B1
• Alliance: Klhl24^em1Xtan page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 1.9 kb deletion. (J:327299)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klhl24 Mutation: 35 strains or lines available

References

• Original: J:327299 Lin Z, et al., Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility. Nat Genet. 2016 Dec;48(12):1508-1516
• All: 2 reference(s)