Tti1^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tti1^em1(IMPC)J
• Name: TELO2 interacting protein 1; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:7428768
• Synonyms: Tti1^-
• Gene: Tti1 Location: Chr2:157823723-157870353 bp, - strand Genetic Position: Chr2, 78.68 cM
• Alliance: Tti1^em1(IMPC)J page
• IMPC: Tti1 gene page

Tti1^em1(IMPC)J/Tti1^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form typical outgrowths.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory using Cas9 and guides with spacer sequences CTGTCAGCTCAAATGCCAAG and GTATAAGAGTTGTCCTGAGG that targeted exon(s) ENSMUSE00001259605.2 ENSMUSE00001282578.2. This resulted in deletion(s) of 2 bp (location: Chr2:157843018-157843019; GRCm39), 4131 bp (location: Chr2:157838811-157842941; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tti1 Mutation: 46 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 4 reference(s)