Cldn5^tm1.1Tac
Targeted Allele Detail

Summary

• Symbol: Cldn5^tm1.1Tac
• Name: claudin 5; targeted mutation 1.1, Taconic
• MGI ID: MGI:7428762
• Synonyms: Cldn5^flox
• Gene: Cldn5 Location: Chr16:18595597-18597012 bp, + strand Genetic Position: Chr16, 11.63 cM
• Alliance: Cldn5^tm1.1Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:327376
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of the 5' UTR and an FRT-flanked puromycin resistance cassette with a 3' loxP site downstream of the 3' UTR. Flp-mediated recombination removed the selection cassette. (J:327376)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn5 Mutation: 26 strains or lines available

References

• Original: J:327376 Richards M, et al., Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner. Elife. 2022 Jul 21;11:e78517
• All: 1 reference(s)