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Slc39a5tm1.1Fudi
Targeted Allele Detail
Summary
Symbol: Slc39a5tm1.1Fudi
Name: solute carrier family 39 (metal ion transporter), member 5; targeted mutation 1.1, Fudi Wang
MGI ID: MGI:7428754
Synonyms: Slc39a5fl
Gene: Slc39a5  Location: Chr10:128231800-128237098 bp, - strand  Genetic Position: Chr10, 76.55 cM, cytoband D3
Alliance: Slc39a5tm1.1Fudi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:279170
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked PGK-neomycin selection cassette and a loxP site were inserted upstream of exon 4 and a second loxP site was inserted downstream of exon 4. The neomycin selection cassette was removed via flp-mediated recombination leaving exon 4 floxed. (J:279170)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc39a5 Mutation:  28 strains or lines available
References
Original:  J:279170 Wang X, et al., The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic beta-cells via Sirt1- and Pgc-1alpha-mediated regulation of Glut2. Protein Cell. 2019 Jun;10(6):436-449
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory