Aff3^em1Kyas
Endonuclease-mediated Allele Detail

Summary

• Symbol: Aff3^em1Kyas
• Name: AF4/FMR2 family, member 3; endonuclease-mediated mutation 1, Koji Yasutomo
• MGI ID: MGI:7428743
• Synonyms: Aff3-floxed
• Gene: Aff3 Location: Chr1:38216407-38704036 bp, - strand Genetic Position: Chr1, 16.58 cM
• Alliance: Aff3^em1Kyas page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exons 2 through 4. (J:327834)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aff3 Mutation: 51 strains or lines available

References

• Original: J:327834 Tsukumo SI, et al., AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination. Sci Adv. 2022 Aug 26;8(34):eabq0008
• All: 1 reference(s)