Sf3b1^tm1Schwk
Targeted Allele Detail

Summary

• Symbol: Sf3b1^tm1Schwk
• Name: splicing factor 3b, subunit 1; targeted mutation 1, Gerald Schwank
• MGI ID: MGI:7428720
• Synonyms: Sf3b1^flox
• Gene: Sf3b1 Location: Chr1:55024328-55066640 bp, - strand Genetic Position: Chr1, 27.98 cM
• Alliance: Sf3b1^tm1Schwk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:327878
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exons 5 and 6. A neomycin selection cassette was inserted upstream of exon 5. (J:327878)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sf3b1 Mutation: 77 strains or lines available

References

• Original: J:327878 Simmler P, et al., SF3B1 facilitates HIF1-signaling and promotes malignancy in pancreatic cancer. Cell Rep. 2022 Aug 23;40(8):111266
• All: 1 reference(s)