Erbb4^tm1.2Bnno
Targeted Allele Detail

Summary

• Symbol: Erbb4^tm1.2Bnno
• Name: erb-b2 receptor tyrosine kinase 4; targeted mutation 1.2, Andres Buonanno
• MGI ID: MGI:7428656
• Synonyms: Cyt-1^-
• Gene: Erbb4 Location: Chr1:68071345-69147218 bp, - strand Genetic Position: Chr1, 33.8 cM
• Alliance: Erbb4^tm1.2Bnno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:327942
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted a loxP site downstream of exon 26 and an FRT-flanked neomycin resistance cassette with a 5' loxP site. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed the Cyt-1 isoform-specific exon 26 preventing expression of the isoform. (J:327942)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb4 Mutation: 87 strains or lines available

References

• Original: J:327942 Erben L, et al., Developmental, neurochemical, and behavioral analyses of ErbB4 Cyt-1 knockout mice. J Neurochem. 2022 Jun;161(5):435-452
• All: 2 reference(s)