Neurod2tm1c(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Neurod2tm1c(KOMP)Wtsi |
Name: |
neurogenic differentiation 2; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:7428644 |
Synonyms: |
Neurod2flox |
Gene: |
Neurod2 Location: Chr11:98216241-98220471 bp, - strand Genetic Position: Chr11, 61.75 cM
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Alliance: |
Neurod2tm1c(KOMP)Wtsi page
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Mutant Cell Line: |
EPD0422_5_B06 |
Germline Transmission: |
Earliest citation of germline transmission:
J:313940
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
Vector: L1L2_Pgk_P
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Mutation details: The L1L2_Pgk_P cassette was inserted at position 98216249 of Chromosome 11 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 2 at position 98219618. The critical exon 2 is thus flanked by loxP sites. Flp-mediated recombination removed the lacZ and neomycin resistance gene and generated a "conditional ready" allele was created in which exon 2 is floxed. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:313940)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Neurod2 Mutation: |
23 strains or lines available
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Original: |
J:313940 Runge K, et al., Disruption of NEUROD2 causes a neurodevelopmental syndrome with autistic features via cell-autonomous defects in forebrain glutamatergic neurons. Mol Psychiatry. 2021 Jun 29; |
All: |
1 reference(s) |
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