Rag1^em1Mvw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rag1^em1Mvw
• Name: recombination activating 1; endonuclease-mediated mutation 1, Michael Wiles
• MGI ID: MGI:7428597
• Synonyms: 129R
• Gene: Rag1 Location: Chr2:101468627-101479846 bp, - strand Genetic Position: Chr2, 53.88 cM
• Alliance: Rag1^em1Mvw page

Mutation origin

• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Single point mutation
• Mutation details: The CRISPR/Cas9 base editor BE4Max was used to convert the glutamine codon at position 192 to a stop codon (Q192X, CAG to TAG), resulting in an early termination allele predicted to be a null. (J:332675)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rag1 Mutation: 133 strains or lines available

References

• Original: J:332675 Sargent JK, et al., Genetically diverse mouse platform to xenograft cancer cells. Dis Model Mech. 2022 Sep;15(9)
• All: 1 reference(s)