Rr344^em1Jfer
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr344^em1Jfer
• Name: regulatory region 344; endonuclease-mediated mutation 1, Jorge Ferrer
• MGI ID: MGI:7428576
• Synonyms: Ptf1a^enhDelta
• Gene: Rr344 Location: unknown Genetic Position: Chr2, Syntenic
• Alliance: Rr344^em1Jfer page

Mutation origin

• Strain of Origin: (C57BL/6J x CBA/CaCrl)F1

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: CRISPR-targeting deleted 393 bp containing the orthologous mouse sequence of the human pancreas agenesis enhancer (PTF1A^enhP). (J:328047)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr344 Mutation: 0 strains or lines available

References

• Original: J:328047 Miguel-Escalada I, et al., Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster. Dev Cell. 2022 Aug 22;57(16):1922-1936.e9
• All: 1 reference(s)