Gt(ROSA)26Sor^{em2(CAG-KIRREL_i2,-EGFP)Fxyu}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em2(CAG-KIRREL_i2,-EGFP)Fxyu}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 2, Fa-Xing Yu
• MGI ID: MGI:7428558
• Synonyms: R26-e(CAG-LSL-hKIRRELisoform2-IRES-EGFP-PolyA)
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em2(CAG-KIRREL_i2,-EGFP)Fxyu} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: CRISPR-targeting introduced the CAG promoter, a floxed stop cassette, the human sequence for isoform 2, IRES, and EGFP reporter gene. (J:328134)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:328134 Gu Y, et al., Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers. Cell Rep. 2022 Aug 30;40(9):111296
• All: 1 reference(s)